Navigating the Complexities of Spike-in Normalization in ChIP-seq Experiments

Navigating the Complexities of Spike-in Normalization in ChIP-seq Experiments Spike-in normalization has emerged as a pivotal technique in chromatin immunoprecipitation sequencing (ChIP-seq) experiments, offering a method to improve the sensitivity and accuracy of detecting genome-wide changes. This technique involves adding a known quantity of chromatin to a sample before analysis, which helps account for variations […]